After the emotional strain of the events of the past two issues, the Space Ghost family gets no reprieve. The Sorceress Prospero has her sights on eliminating them once and for all. How can the family come together and defeat a foe that they can’t see?

The Antimatter Man has gone full on mad, and it is up to the Space Ghost family to stop him. But how will Jace & Jan feel when they find out the Antimatter Man is their grandfather? Can Space Ghost save not just the workers of Contra Industries, but also Henry Contra himself?

Jan and Jace’s Grandfather Dr. Henry Contra is about to unveil his new revolutionary invention, the Antimatter Generator. Unfortunately, no one knows that a traitor has given access to Dr. Cyclo who intends on sabotaging the unveiling. However, no one could have guessed the consequences of this action.

Space Ghost, Jan, and Jace run into their biggest threat yet, vampires. As they fight to stay alive in the dark, Space Ghost gets bitten and turns. Can Jan & Jace not only survive, but also save Space Ghost in the process?