The world is caught between a new kind of war. One where humans no longer need to just fear mutants, but also other humans so to speak. Vampires have invaded the world, but unfortunately for them they infected some very powerful mutants. This led to war between the two different species of vampires, the human ones and the mutant ones known as empyres. But now Cardinal Stryker has ordered his holy troops to kill off the empyres, which will surely cause a three-way war. Bishop Wagner and the last X-Man are all that can stand in the way and possibly save the day.